FDA Warns: Breathing Risks with Gabapentin and Pregabalin

Got a prescription for gabapentin or pregabalin? You might have heard the FDA just raised a red flag about these drugs. The agency says they can cause serious breathing problems, especially when you’re also taking opioids or other central nervous system depressants.

Why the warning matters

Gabapentin and pregabalin are popular for nerve pain, seizures, and restless‑leg syndrome. They work by calming nerve activity, which most people find helpful. But the FDA’s latest data shows that in some patients the drugs can slow breathing too much. This isn’t just a mild side effect – it can be life‑threatening, particularly for older adults or folks with COPD, asthma, or sleep apnea.

What’s driving the risk? When gabapentin or pregabalin are stacked with opioids, the combined effect can push the respiratory system into a dangerous slowdown. Think of it like two brakes being pressed at once – you might not notice the slowdown until it’s too late.

What you should do now

If you’re already on one of these meds, don’t panic, but do take action. Talk to your doctor about any breathing issues, even mild shortness of breath. Your prescriber might lower the dose, switch to a different medication, or set up closer monitoring, especially if you’re over 65 or have a lung condition.

For anyone starting gabapentin or pregabalin, ask the pharmacist about the new warning label. It will list the breathing risk and advise you to watch for symptoms like shallow breathing, sudden fatigue, or feeling “out of breath” after minimal activity.

And if you’re on both an opioid and one of these nerve‑pain drugs, the conversation is even more critical. Your doctor may suggest alternative pain relief options, such as non‑opioid anti‑inflammatories, physical therapy, or newer nerve‑pain agents that don’t interact the same way.

Finally, stay alert for any new safety trials that the FDA is mandating. These studies aim to pinpoint which patients are most vulnerable and how to adjust dosing safely. Keeping up with updates can help you and your healthcare team make informed choices.

Bottom line: Gabapentin and pregabalin are still useful, but the breathing risk is real, especially with opioids. Talk openly with your doctor, watch for warning signs, and stay informed about label changes. Your safety depends on staying proactive and keeping the lines of communication open.